ABSTRACT
Objective To investigate the relationship between epidermal growth factor receptor (EGFR) gene mutation and computed tomography (CT) features and clinical features in non-small cell lung cancer (NSCLCs) patients. Methods The clinical data of 187 patients with NSCLCs admitted in our hospital from September 2014 to July 2016 were retrospectively analyzed. All the patients accepted the EGFR mutated gene detection, and they were divided into effective mutation group (n=67) and non-effective mutation group (n=120). The clinical data and lung CT imaging data were complete in the two groups. The univariate and multivariate Logistic regression analysis were used to analyze the differences of imaging and clinical features between the two groups. Results Comparing with the non-mutation group, there were higher proportion of women and lower smoking index in the EGFR effective mutation group. Lesions in the lung tissue showed a clear edge, leaf and burr, and containing ground-glass opacity (GGO) component, usually accompanied by airway bronchogram and pleural indentation, and associated with cancer lymphatic inflammation and lung metastasis in mutation group (all P < 0.05). There were no significant differences in the proportion of necrosis, cavitation, calcification, halo sign and vacuole sign between the two groups (P > 0.05). Logistic regression analysis showed that female, GGO containing composition, burr, air bronchogram, carcinomatous lymphangitis and lesion density showed obvious airway involvement were the predictive risk factors in patients with EGFR effective mutation. Conclusion The EGFR mutation occurs more oftern in female. The reliable predictive signs of CT include GGO composition, burr, airway bronchogram and carcinoid lymphangitis. In critical patients who are not easy to obtain clinical pathology, it has a guiding significance to radiographic assessment for EGFR effective mutation.
ABSTRACT
To report a case with primary lung mucosa-associated lymphoid tissue type marginal zone B-cell lymphoma (PMZL-MALT). The patient was admitted in our hospital mainly due to intermittent cough and expectoration for 4 years, and aggravating for 1 year. The anti-infective treatment was given to this patient, and the efficacy was not good. Laboratory tests showed no specific indicators. Chest enhancement CT examination showed pulmonary consolidation lesions. After taking biopsy by tracheoscopy and pathological examination, the diagnosis of mucosa-associated lymphoid tissue type marginal zone B-cell lymphoma was confirmed. After receiving chemotherapy, the patient remains under treatment in a stable condition and regular reexamination.
ABSTRACT
To report a case with primary lung mucosa-associated lymphoid tissue type marginal zone B-cell lymphoma (PMZL-MALT). The patient was admitted in our hospital mainly due to intermittent cough and expectoration for 4 years, and aggravating for 1 year. The anti-infective treatment was given to this patient, and the efficacy was not good. Laboratory tests showed no specific indicators. Chest enhancement CT examination showed pulmonary consolidation lesions. After taking biopsy by tracheoscopy and pathological examination, the diagnosis of mucosa-associated lymphoid tissue type marginal zone B-cell lymphoma was confirmed. After receiving chemotherapy, the patient remains under treatment in a stable condition and regular reexamination.
ABSTRACT
Objective To mvesugate the Tate of YMDD mutation accompamed with pre-core(region and core promotor region mutation and the clinical significance.Methods YMDD mutation and pre-core(at 1896 nu- cleotide)region and core promotor region(at 1762.1764 nucleotide)mutation were detected from the 122 patients with chronic hepatitis B virus after receiving lamivudine treatment above 6 months.Results 40 cases were tested for YMDI)mutations in 122 HBV patients with lamivudine treatment,and the positive rate of YMDD mutation was 32.8 %.After YMDD mutation,ALT,AST and HBV DNA of the patients significantly increased(P0.05).Conclusion The patients with YMDD mutation had higher rate of pre-core region(at 1896 nucleotide)and basal core promotor region(at 1762, 1764 nucleotide)mutation than those without YMDD mutation,but there was no correlation between the mutation and the deterioration of disease condition and the bad prognosis.